{"id":4673,"date":"2021-03-30T14:36:06","date_gmt":"2021-03-30T14:36:06","guid":{"rendered":"https:\/\/www.biobank.lv\/?p=4673"},"modified":"2022-03-25T13:09:47","modified_gmt":"2022-03-25T13:09:47","slug":"cilmes-sunu-injekcijas-dod-iespeju-atlabt-pacientiem-ar-muguras-smadzenu-traumam","status":"publish","type":"post","link":"https:\/\/www.biobank.lv\/ru\/cilmes-sunu-injekcijas-dod-iespeju-atlabt-pacientiem-ar-muguras-smadzenu-traumam\/","title":{"rendered":"Cilmes \u0161\u016bnu injekcijas dod iesp\u0113ju atlabt pacientiem ar muguras smadze\u0146u traum\u0101m"},"content":{"rendered":"

Mugurkaula traum\u0101m var b\u016bt posto\u0161as sekas, t\u0101das k\u0101 piln\u012bgs vai da\u013c\u0113js saj\u016btu vai kust\u012bbu zudums zem traumas vietas, k\u0101 ar\u012b citas probl\u0113mas, kas ir milz\u012bgs izaicin\u0101jums gan pacientiem, gan vi\u0146u apr\u016bp\u0113t\u0101jiem.<\/p>\n

P\u0113d\u0113jos gados cilmes \u0161\u016bnu transplant\u0101cija tiek uzskat\u012bta k\u0101 potenci\u0101ls l\u012bdzeklis iepriek\u0161 ne\u0101rst\u0113jamu muguras smadze\u0146u traumu (SCI) \u0101rst\u0113\u0161anai. \u0160ai cilmes \u0161\u016bnu terapijai ir liels potenci\u0101ls pal\u012bdz\u0113t muguras smadze\u0146u traumu pacientu rehabilit\u0101cij\u0101. Jo \u012bpa\u0161i mezenhim\u0101l\u0101s cilmes \u0161\u016bnas no nabassaites audiem ir izrais\u012bju\u0161as lielu interesi zin\u0101tnieku aprind\u0101s, pateicoties ieg\u016b\u0161anas vienk\u0101r\u0161\u012bbai, \u0101trai pavairo\u0161anai, pretiekaisumu iedarb\u012bbai un sp\u0113jai veicin\u0101t citu \u0161\u016bnu izdz\u012bvo\u0161anu.<\/p>\n

Pacientu ar muguras smadze\u0146u traum\u0101m vesel\u012bbas st\u0101vokl\u012b p\u0113c nabassaites cilmes \u0161\u016bnu terapijas ir nov\u0113rojami uzlabojumi.<\/strong><\/p>\n

2020. gada nogal\u0113 public\u0113taj\u0101 p\u0113t\u012bjum\u0101 tika zi\u0146ots par nabassaites audu mezenhim\u0101lo cilmes \u0161\u016bnu pielieto\u0161anas efektivit\u0101ti 41 pacientam ar hronisk\u0101m muguras smadze\u0146u traum\u0101m. Pacientiem vecum\u0101 no 18 l\u012bdz 65 gadiem muguras smadzenes bija cietu\u0161as, galvenok\u0101rt, ce\u013cu satiksmes negad\u012bjumu vai kritienu rezult\u0101t\u0101. Laika interv\u0101ls starp traumas g\u016b\u0161anu un cilmes \u0161\u016bnu terapijas s\u0101kumu bija no 2 m\u0113ne\u0161iem l\u012bdz 20 gadiem ilgs. Katrs dal\u012bbnieks sa\u0146\u0113ma 4 mezenhim\u0101lo cilmes \u0161\u016bnu injekcijas mugurkaula jostas da\u013cas rajon\u0101. Injekcijas tika veiktas ar viena m\u0113ne\u0161a starp\u012bbu, un pacienti tika nov\u0113roti vienu gadu p\u0113c p\u0113d\u0113j\u0101s injekcijas.<\/p>\n

Kas attiecas uz eksperiment\u0101l\u0101s \u0101rst\u0113\u0161anas efektivit\u0101ti, iev\u0113rojami uzlabojumi tika nov\u0113roti da\u017e\u0101dos testos, kas tika izmantoti, lai m\u0113r\u012btu pacientu progres\u0113\u0161anu da\u017e\u0101dos l\u012bme\u0146os, piem\u0113ram, attiec\u012bb\u0101 uz mobilit\u0101ti, sfinktera kontroli, ur\u012bnp\u016b\u0161\u013ca un zarnu funkciju uzlabojumiem, s\u0101p\u0113m, musku\u013cu sasprindzin\u0101jumu un sp\u0113ju veikt ikdienas pamatuzdevumus. Pamatojoties uz \u0161iem uzlabojumiem, var secin\u0101t, ka dal\u012bbnieki ieguva dz\u012bves kvalit\u0101ti p\u0113c eksperiment\u0101l\u0101s \u0101rst\u0113\u0161anas. Analiz\u0113jot pacientu apak\u0161grupas, tika atkl\u0101ts, ka cilmes \u0161\u016bnu terapijas ieguvums tika konstat\u0113ts gan pacientiem traumas agr\u012bn\u0101 stadij\u0101, t\u0101pat k\u0101 pacientiem ar ievainojumiem, kas konstat\u0113ti pirms vair\u0101kiem gadiem, gan ar traum\u0101m jebkur\u0101 mugurkaula da\u013c\u0101 (kakla, kr\u016b\u0161u vai jostas da\u013c\u0101). Turkl\u0101t eksperiment\u0101l\u0101 terapija ir izr\u0101d\u012bjusies efekt\u012bva gan pacientiem ar nepiln\u012bgiem, gan piln\u012bgiem boj\u0101jumiem – tie parasti ir smag\u0101k\u0101 st\u0101vokl\u012b un ar \u013coti neliel\u0101m iesp\u0113j\u0101m atg\u016bties. \u0160aj\u0101 p\u0113t\u012bjum\u0101 dati par dro\u0161\u012bbu un efektivit\u0101ti ir daudzsolo\u0161i, paverot ce\u013cu turpm\u0101kiem kl\u012bniskiem p\u0113t\u012bjumiem, lai apstiprin\u0101tu \u0161o tehniku \u200b\u200bun t\u0101s ievie\u0161anu pa\u0161reiz\u0113j\u0101 kl\u012bniskaj\u0101 praks\u0113.<\/p>\n

Neskatoties uz labajiem rezult\u0101tiem, kuri sasniegti \u0161aj\u0101 kl\u012bniskaj\u0101 p\u0113t\u012bjum\u0101, kas ir labv\u0113l\u012bgi nabassaites cilmes \u0161\u016bnu izmanto\u0161anai hronisku, piln\u012bgu vai nepiln\u012bgu muguras smadze\u0146u traumu \u0101rst\u0113\u0161an\u0101, autori uzsver, ka \u0161aj\u0101 p\u0113t\u012bjum\u0101 nebija iek\u013cauta kontroles grupa, t\u0101p\u0113c ir oblig\u0101ti veikt randomiz\u0113tus kl\u012bniskos p\u0113t\u012bjumus ar liel\u0101ku pacientu skaitu un kontroles grupu, lai apstiprin\u0101tu tagad public\u0113tos rezult\u0101tus.<\/p>\n

 <\/p>\n

Izmantotie inform\u0101cijas avoti:<\/p>\n

    \n
  1. https:\/\/www.crioestaminal.pt\/injecao-celulas-estaminais-permite-recuperacao-doentes-lesoes-na-espinal-medula\/<\/a><\/li>\n
  2. https:\/\/pubmed.ncbi.nlm.nih.gov\/33218835\/<\/a><\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"

    Mugurkaula traum\u0101m var b\u016bt posto\u0161as sekas, t\u0101das k\u0101 piln\u012bgs vai da\u013c\u0113js saj\u016btu vai kust\u012bbu zudums zem traumas vietas, k\u0101 ar\u012b citas probl\u0113mas, kas ir milz\u012bgs izaicin\u0101jums gan pacientiem, gan vi\u0146u apr\u016bp\u0113t\u0101jiem. P\u0113d\u0113jos gados cilmes \u0161\u016bnu transplant\u0101cija tiek uzskat\u012bta k\u0101 potenci\u0101ls l\u012bdzeklis iepriek\u0161 ne\u0101rst\u0113jamu muguras smadze\u0146u traumu (SCI) \u0101rst\u0113\u0161anai. \u0160ai cilmes \u0161\u016bnu terapijai ir liels potenci\u0101ls […]<\/p>\n","protected":false},"author":1,"featured_media":5419,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[58],"tags":[],"class_list":["post-4673","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jaunumi1"],"yoast_head":"\nCilmes \u0161\u016bnu injekcijas dod iesp\u0113ju atlabt pacientiem ar muguras smadze\u0146u traum\u0101m | BIOBANK<\/title>\n<meta name=\"description\" content=\"Analiz\u0113jot pacientu apak\u0161grupas, tika atkl\u0101ts, ka cilmes \u0161\u016bnu terapijas ieguvums tika konstat\u0113ts gan pacientiem traumas agr\u012bn\u0101 stadij\u0101, gan 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