{"id":4685,"date":"2021-04-14T11:14:55","date_gmt":"2021-04-14T11:14:55","guid":{"rendered":"https:\/\/www.biobank.lv\/?p=4685"},"modified":"2022-03-25T12:49:36","modified_gmt":"2022-03-25T12:49:36","slug":"nabassaites-asins-sunu-pavairosana","status":"publish","type":"post","link":"https:\/\/www.biobank.lv\/ru\/nabassaites-asins-sunu-pavairosana\/","title":{"rendered":"Nabassaites asins \u0161\u016bnu pavairo\u0161ana laboratorij\u0101 \u013cauj palielin\u0101t transplant\u0113to \u0161\u016bnu skaitu"},"content":{"rendered":"

Kop\u0161 pirm\u0101s transplant\u0101cijas 1988. gad\u0101, nabassaites asinis ir k\u013cuvu\u0161as par noz\u012bm\u012bgu cilmes \u0161\u016bnu avotu asinsrades transplant\u0101cij\u0101m, ar kur\u0101m ir iesp\u0113jams \u0101rst\u0113t hemato-onkolo\u0123isk\u0101s saslim\u0161anas, im\u016bndefic\u012btus, vielmai\u0146as un v\u0113l citas slim\u012bbas.<\/p>\n

Mediju telp\u0101 k\u0101 arguments topo\u0161iem vec\u0101kiem, kas dom\u0101 par nabassaites cilmes \u0161\u016bnu saglab\u0101\u0161anu, visbie\u017e\u0101k par\u0101d\u0101s apgalvojums tam, ka nabassaites asins cilmes \u0161\u016bnu izmanto\u0161anai, lai \u0101rst\u0113tu pacientus ar liel\u0101ku \u0137erme\u0146a svaru, nepietiks ar saglab\u0101to \u0161\u016bnu skaitu asins paraugos.<\/p>\n

\u0160ajos gad\u012bjumos strat\u0113\u0123ija, kas veiksm\u012bgi izmantota p\u0113d\u0113jos 20 gadus, ir divu sagatavoto nabassaites asins paraugu transplant\u0101cija viena viet\u0101. V\u0113l viens p\u0113t\u012bts risin\u0101jums ir nabassaites asins \u0161\u016bnu pavairo\u0161ana laboratorij\u0101 pirms transplant\u0101cijas. \u0160\u012b pieeja \u013cauj ieg\u016bt lielu skaitu cilmes \u0161\u016bnu no sal\u012bdzino\u0161i neliel\u0101 s\u0101kotn\u0113j\u0101 skaita. T\u0101p\u0113c m\u016bsdienu medic\u012bn\u0101 tiek p\u0101rbaud\u012btas da\u017e\u0101das metodikas un da\u017eas no t\u0101m ir jau uzr\u0101d\u012bju\u0161as daudzsolo\u0161us rezult\u0101tus.<\/p>\n

P\u0113t\u012bjumu rezult\u0101ti virza nabassaites asins kultiv\u0113\u0161anas jeb pavairo\u0161anas metodes tuv\u0101k to izmanto\u0161anai kl\u012bniku ikdien\u0101.<\/strong><\/p>\n

Viena no p\u0113t\u0101maj\u0101m metodik\u0101m, kas izce\u013cas ar p\u0113d\u0113jos gados ieg\u016btajiem labajiem rezult\u0101tiem, k\u0101 pamatu savai asins \u0161\u016bnu pavairo\u0161anas tehnolo\u0123ijai izmanto nikot\u012bnam\u012bda molekulu. Uz nikotinam\u012bda b\u0101zes balst\u012bta \u0161\u016bnu pavairo\u0161anas tehnolo\u0123ija \u013cauj donoru \u0161\u016bn\u0101m augt un vairoties, saglab\u0101jot funkcionalit\u0101ti. \u0160\u016bnu pavairo\u0161anas rezult\u0101t\u0101 ieg\u016bto produktu sauc par Omidubicel<\/em>.<\/p>\n

2020. gad\u0101 p\u0101rliecino\u0161i pozit\u012bvi Omidubicel\u00a0<\/em>darb\u012bbas rezult\u0101ti tika pazi\u0146oti III f\u0101zes kl\u012bniskaj\u0101 p\u0113t\u012bjum\u0101, kur\u0101 piedal\u012bj\u0101s 125 pacienti ar \u013caundab\u012bg\u0101m asins saslim\u0161an\u0101m, un, kuri tika \u0101rst\u0113ti vair\u0101k k\u0101 50 transplant\u0101cijas centros ASV, Dienvidamerik\u0101, Eirop\u0101 un \u0100zij\u0101. \u0160aj\u0101 p\u0113t\u012bjum\u0101 tika nov\u0113rots, ka vid\u0113jais asins atvese\u013co\u0161an\u0101s laiks p\u0113c transplant\u0101cijas pacientiem, kuri sa\u0146\u0113ma Omidubicel<\/em>, bija iev\u0113rojami \u012bs\u0101ks, sal\u012bdzinot ar tiem, kuri sa\u0146\u0113ma nepavairot\u0101s nabassaites asinis. Atvese\u013co\u0161an\u0101s laiks ir tie\u0161i saist\u0101ms ar maz\u0101k\u0101m komplik\u0101cij\u0101m un \u012bs\u0101ku uztur\u0113\u0161anos slimn\u012bc\u0101. Lai \u0161\u012b metodika k\u013c\u016btu pieejama, pieteikums licencei \u0161ogad tiks iesniegts Amerikas a\u0123ent\u016brai FDA.<\/p>\n

V\u0113l viena metode, kas ar\u012b uzr\u0101d\u012bjusi labus rezult\u0101tus, nabassaites asins cilmes \u0161\u016bnu pavairo\u0161anas nol\u016bkos izmanto molekulu ar nosaukumu UM171, un t\u0101 tika izstr\u0101d\u0101ta Kan\u0101d\u0101. 2020. gada janv\u0101ra publik\u0101cij\u0101 The Lancet Hematology\u00a0<\/em>aprakst\u012bti I\/II f\u0101zes kl\u012bnisk\u0101 p\u0113t\u012bjuma rezult\u0101ti, kur\u0101 transplant\u0101cijas veiksm\u012bgi tika veiktas 22 pieaugu\u0161ajiem ar hemato-onkolo\u0123isk\u0101m saslim\u0161an\u0101m, izmantojot ar \u0161o molekulu pavairot\u0101s nabassaites asinis. \u0160aj\u0101 p\u0113t\u012bjum\u0101 secin\u0101jumi gan attiec\u012bb\u0101 uz asins atvese\u013co\u0161an\u0101s laiku, gan izdz\u012bvo\u0161anas r\u0101d\u012bt\u0101jiem un komplik\u0101cij\u0101m p\u0113c transplant\u0101cijas bija \u013coti labv\u0113l\u012bgi.<\/p>\n

Nesen \u0161\u012b pati p\u0113tnieku grupa public\u0113ja veiksm\u012bgu nabassaites asins cilmes \u0161\u016bnu izmanto\u0161anas gad\u012bjumu, veicot \u0161\u016bnu transplant\u0101ciju 29 gadus vecam, 80kg smagam v\u012brietim, kur\u0161 cieta no smagas aplastiskas an\u0113mijas. S\u0101kotn\u0113ji pacients tika \u0101rst\u0113ts ar im\u016bnsupresantiem, bet p\u0113c 58 asins p\u0101rlie\u0161an\u0101m, vi\u0146\u0161 galu gal\u0101 tika nos\u016bt\u012bts uz transplant\u0101ciju. T\u0101 k\u0101 nebija iesp\u0113jams atrast sader\u012bgu kaulu smadze\u0146u donoru, pacientam tika ievad\u012btas laboratorij\u0101 pavairotas nabassaites asins \u0161\u016bnas. V\u012brietim kl\u0101jas labi un jau tr\u012bs gadus vi\u0146\u0161 dz\u012bvo bez \u0161\u012bs slim\u012bbas.<\/p>\n

\u0160ie rezult\u0101ti liecina, ka da\u017e\u0101das nabassaites asins \u0161\u016bnu pavairo\u0161anas metodikas laboratorij\u0101 ir ieguvu\u0161as labv\u0113l\u012bgus rezult\u0101tus kl\u012bniskajos p\u0113t\u012bjumos, k\u013c\u016bstot arvien tuv\u0101kas apstiprin\u0101\u0161anai kl\u012bniskai lieto\u0161anai. Tas \u013caus katram pacientam izv\u0113l\u0113ties \u0101rst\u0113\u0161anas metodi ar cilmes \u0161\u016bn\u0101m ar visliel\u0101ko atbilst\u012bbu, neraiz\u0113joties par pieejamo \u0161\u016bnu daudzumu.<\/p>\n

 <\/p>\n

\u0418\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u043d\u044b\u0435 \u043b\u0438\u0442\u0435\u0440\u0430\u0442\u0443\u0440\u043d\u044b\u0435 \u0438\u0441\u0442\u043e\u0447\u043d\u0438\u043a\u0438:<\/p>\n

https:\/\/www.researchgate.net\/publication\/343435861_Single_UM171-expanded_cord_blood_transplant_can_cure_severe_idiopathic_aplastic_anemia_in_absence_of_suitable_donors<\/a><\/p>\n

https:\/\/www.unboundmedicine.com\/medline\/citation\/31704264\/Hematopoietic_stem_cell_transplantation_using_single_UM171_expanded_cord_blood:_a_single_arm_phase_1_2_safety_and_feasibility_study_<\/a><\/p>\n

https:\/\/investors.gamida-cell.com\/news-events\/press-releases\/news-release-details\/gamida-cell-announces-positive-topline-data-phase-3<\/a><\/p>\n

https:\/\/investors.gamida-cell.com\/news-events\/press-releases\/news-release-details\/gamida-cell-announces-omidubicel-secondary-endpoints<\/a><\/p>\n

http:\/\/www.gamida-cell.com\/wp-content\/uploads\/Omidubicel-Fact-Sheet.pdf<\/a><\/p>\n

https:\/\/adisinsight.springer.com\/drugs\/800034388<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Kop\u0161 pirm\u0101s transplant\u0101cijas 1988. gad\u0101, nabassaites asinis ir k\u013cuvu\u0161as par noz\u012bm\u012bgu cilmes \u0161\u016bnu avotu asinsrades transplant\u0101cij\u0101m, ar kur\u0101m ir iesp\u0113jams \u0101rst\u0113t hemato-onkolo\u0123isk\u0101s saslim\u0161anas, im\u016bndefic\u012btus, vielmai\u0146as un v\u0113l citas slim\u012bbas. Mediju telp\u0101 k\u0101 arguments topo\u0161iem vec\u0101kiem, kas dom\u0101 par nabassaites cilmes \u0161\u016bnu saglab\u0101\u0161anu, visbie\u017e\u0101k par\u0101d\u0101s apgalvojums tam, ka nabassaites asins cilmes \u0161\u016bnu izmanto\u0161anai, lai \u0101rst\u0113tu pacientus […]<\/p>\n","protected":false},"author":1,"featured_media":5416,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[58],"tags":[],"class_list":["post-4685","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jaunumi1"],"yoast_head":"\nNabassaites asins \u0161\u016bnu pavairo\u0161ana laboratorij\u0101 \u013cauj palielin\u0101t transplant\u0113to \u0161\u016bnu skaitu | BIOBANK<\/title>\n<meta name=\"description\" content=\"Nabassaites asins cilmes \u0161\u016bnu pavairo\u0161anas metodikas ir ieguvu\u0161as labv\u0113l\u012bgus rezult\u0101tus, kas \u013caus katram pacientam izv\u0113l\u0113ties \u0101rst\u0113\u0161anas metodi ar cilmes \u0161\u016bn\u0101m ar visliel\u0101ko atbilst\u012bbu, neraiz\u0113joties par pieejamo \u0161\u016bnu daudzumu.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.biobank.lv\/ru\/nabassaites-asins-sunu-pavairosana\/\" \/>\n<meta property=\"og:locale\" content=\"ru_RU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nabassaites asins \u0161\u016bnu pavairo\u0161ana laboratorij\u0101 \u013cauj palielin\u0101t transplant\u0113to \u0161\u016bnu skaitu | BIOBANK\" \/>\n<meta property=\"og:description\" content=\"Nabassaites asins cilmes \u0161\u016bnu pavairo\u0161anas metodikas ir ieguvu\u0161as labv\u0113l\u012bgus rezult\u0101tus, kas \u013caus katram pacientam izv\u0113l\u0113ties \u0101rst\u0113\u0161anas metodi ar cilmes \u0161\u016bn\u0101m ar 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